Occurrence and severity of lung lesions in slaughter pigs vaccinated against Mycoplasma hyopneumoniae with different strategies.
Identifieur interne : 000171 ( Main/Exploration ); précédent : 000170; suivant : 000172Occurrence and severity of lung lesions in slaughter pigs vaccinated against Mycoplasma hyopneumoniae with different strategies.
Auteurs : Sonja Hillen [Allemagne] ; Stephan Von Berg [Allemagne] ; Kernt Köhler [Allemagne] ; Manfred Reinacher [Allemagne] ; Hermann Willems [Allemagne] ; Gerald Reiner [Allemagne]Source :
- Preventive veterinary medicine [ 1873-1716 ] ; 2014.
Descripteurs français
- KwdFr :
- Allemagne (épidémiologie), Animaux (MeSH), Bactéries (isolement et purification), Charge bactérienne (médecine vétérinaire), Femelle (MeSH), Mycoplasma hyopneumoniae (isolement et purification), Mâle (MeSH), Pneumonie enzootique du porc (anatomopathologie), Pneumonie enzootique du porc (prévention et contrôle), Pneumonie enzootique du porc (virologie), Pneumonie enzootique du porc (épidémiologie), Poumon (anatomopathologie), Prévalence (MeSH), Réaction de polymérisation en chaine en temps réel (médecine vétérinaire), Suidae (MeSH), Vaccination (médecine vétérinaire), Vaccins antibactériens (administration et posologie), Vaccins antibactériens (pharmacologie), Virus (isolement et purification).
- MESH :
- administration et posologie : Vaccins antibactériens.
- anatomopathologie : Pneumonie enzootique du porc, Poumon.
- isolement et purification : Bactéries, Mycoplasma hyopneumoniae, Virus.
- médecine vétérinaire : Charge bactérienne, Réaction de polymérisation en chaine en temps réel, Vaccination.
- pharmacologie : Vaccins antibactériens.
- prévention et contrôle : Pneumonie enzootique du porc.
- virologie : Pneumonie enzootique du porc.
- épidémiologie : Allemagne, Pneumonie enzootique du porc.
- Animaux, Femelle, Mâle, Prévalence, Suidae.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Animals (MeSH), Bacteria (isolation & purification), Bacterial Load (veterinary), Bacterial Vaccines (administration & dosage), Bacterial Vaccines (pharmacology), Female (MeSH), Germany (epidemiology), Lung (pathology), Male (MeSH), Mycoplasma hyopneumoniae (isolation & purification), Pneumonia of Swine, Mycoplasmal (epidemiology), Pneumonia of Swine, Mycoplasmal (pathology), Pneumonia of Swine, Mycoplasmal (prevention & control), Pneumonia of Swine, Mycoplasmal (virology), Prevalence (MeSH), Real-Time Polymerase Chain Reaction (veterinary), Swine (MeSH), Vaccination (veterinary), Viruses (isolation & purification).
- MESH :
- chemical , administration & dosage : Bacterial Vaccines.
- geographic , epidemiology : Germany.
- epidemiology : Pneumonia of Swine, Mycoplasmal.
- isolation & purification : Bacteria, Mycoplasma hyopneumoniae, Viruses.
- pathology : Lung, Pneumonia of Swine, Mycoplasmal.
- chemical , pharmacology : Bacterial Vaccines.
- prevention & control : Pneumonia of Swine, Mycoplasmal.
- veterinary : Bacterial Load, Real-Time Polymerase Chain Reaction, Vaccination.
- virology : Pneumonia of Swine, Mycoplasmal.
- Animals, Female, Male, Prevalence, Swine.
Abstract
Different vaccination strategies against Mycoplasma hyopneumoniae have been adopted worldwide. Reports from the field indicate varying levels of protection among currently available vaccines. The goal of the present study was to compare the efficacies of three widespread commercial vaccination strategies against M. hyopneumoniae under field conditions. 20 farms were included. 14 farms used different single dose vaccines (vaccine 1 [V1], 8 herds; vaccine 2 [V2], 6 herds); another 6 farms (V3) used a two dose vaccination strategy. Gross lesions of 854 lungs and histopathology from 140 lungs were quantified, and a quantitative PCR was applied to detect M. hyopneumoniae and porcine circovirus 2 (PCV2) DNA in lung tissue (n=140). In addition, porcine reproductive and respiratory disease virus (PRRSV), swine influenza virus (SIV), Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida were tested by qualitative PCR. 53% of lungs were positive for M. hyopneumoniae. 55.9% of lungs showed macroscopic enzootic pneumonia (EP)-like lesions. Lung lesion scores (P<0.001) and M. hyopneumoniae-loads (P<0.008) differed significantly among the vaccination groups, with the most severe cases and highest amounts occurring in V1. Histological alterations differed (P<0.001) between V1 and V3. Lung lesion scores and histopathological changes were significantly correlated, with prevalence and load of M. hyopneumoniae indicating that the applied diagnostic tools are valuable in confirming the prevalence and severity of M. hyopneumoniae infections. Comparing different vaccination strategies against M. hyopneumoniae indicates varying levels of protection. M. hyopneumoniae is still a major problem despite the widely applied vaccination.
DOI: 10.1016/j.prevetmed.2013.12.012
PubMed: 24485705
Affiliations:
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(epidemiology)</term><term>Lung (pathology)</term><term>Male (MeSH)</term><term>Mycoplasma hyopneumoniae (isolation & purification)</term><term>Pneumonia of Swine, Mycoplasmal (epidemiology)</term><term>Pneumonia of Swine, Mycoplasmal (pathology)</term><term>Pneumonia of Swine, Mycoplasmal (prevention & control)</term><term>Pneumonia of Swine, Mycoplasmal (virology)</term><term>Prevalence (MeSH)</term><term>Real-Time Polymerase Chain Reaction (veterinary)</term><term>Swine (MeSH)</term><term>Vaccination (veterinary)</term><term>Viruses (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term><term>Animaux (MeSH)</term><term>Bactéries (isolement et purification)</term><term>Charge bactérienne (médecine vétérinaire)</term><term>Femelle (MeSH)</term><term>Mycoplasma hyopneumoniae (isolement et purification)</term><term>Mâle (MeSH)</term><term>Pneumonie enzootique du porc (anatomopathologie)</term><term>Pneumonie enzootique du porc (prévention et contrôle)</term><term>Pneumonie enzootique du porc (virologie)</term><term>Pneumonie enzootique du porc (épidémiologie)</term><term>Poumon (anatomopathologie)</term><term>Prévalence (MeSH)</term><term>Réaction de polymérisation en chaine en temps réel (médecine vétérinaire)</term><term>Suidae (MeSH)</term><term>Vaccination (médecine vétérinaire)</term><term>Vaccins antibactériens (administration et posologie)</term><term>Vaccins antibactériens (pharmacologie)</term><term>Virus (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Bacterial Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antibactériens</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Pneumonie 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qualifier="pharmacology" xml:lang="en"><term>Bacterial Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pneumonia of Swine, Mycoplasmal</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Pneumonie enzootique du porc</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Bacterial Load</term><term>Real-Time Polymerase Chain Reaction</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Pneumonie enzootique du porc</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pneumonia of Swine, Mycoplasmal</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Pneumonie enzootique du porc</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Prevalence</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mâle</term><term>Prévalence</term><term>Suidae</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Different vaccination strategies against Mycoplasma hyopneumoniae have been adopted worldwide. Reports from the field indicate varying levels of protection among currently available vaccines. The goal of the present study was to compare the efficacies of three widespread commercial vaccination strategies against M. hyopneumoniae under field conditions. 20 farms were included. 14 farms used different single dose vaccines (vaccine 1 [V1], 8 herds; vaccine 2 [V2], 6 herds); another 6 farms (V3) used a two dose vaccination strategy. Gross lesions of 854 lungs and histopathology from 140 lungs were quantified, and a quantitative PCR was applied to detect M. hyopneumoniae and porcine circovirus 2 (PCV2) DNA in lung tissue (n=140). In addition, porcine reproductive and respiratory disease virus (PRRSV), swine influenza virus (SIV), Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida were tested by qualitative PCR. 53% of lungs were positive for M. hyopneumoniae. 55.9% of lungs showed macroscopic enzootic pneumonia (EP)-like lesions. Lung lesion scores (P<0.001) and M. hyopneumoniae-loads (P<0.008) differed significantly among the vaccination groups, with the most severe cases and highest amounts occurring in V1. Histological alterations differed (P<0.001) between V1 and V3. Lung lesion scores and histopathological changes were significantly correlated, with prevalence and load of M. hyopneumoniae indicating that the applied diagnostic tools are valuable in confirming the prevalence and severity of M. hyopneumoniae infections. Comparing different vaccination strategies against M. hyopneumoniae indicates varying levels of protection. M. hyopneumoniae is still a major problem despite the widely applied vaccination. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24485705</PMID><DateCompleted><Year>2014</Year><Month>10</Month><Day>15</Day></DateCompleted><DateRevised><Year>2014</Year><Month>02</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-1716</ISSN><JournalIssue CitedMedium="Internet"><Volume>113</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Mar</Month><Day>01</Day></PubDate></JournalIssue><Title>Preventive veterinary medicine</Title><ISOAbbreviation>Prev. Vet. Med.</ISOAbbreviation></Journal><ArticleTitle>Occurrence and severity of lung lesions in slaughter pigs vaccinated against Mycoplasma hyopneumoniae with different strategies.</ArticleTitle><Pagination><MedlinePgn>580-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.prevetmed.2013.12.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0167-5877(13)00394-2</ELocationID><Abstract><AbstractText>Different vaccination strategies against Mycoplasma hyopneumoniae have been adopted worldwide. Reports from the field indicate varying levels of protection among currently available vaccines. The goal of the present study was to compare the efficacies of three widespread commercial vaccination strategies against M. hyopneumoniae under field conditions. 20 farms were included. 14 farms used different single dose vaccines (vaccine 1 [V1], 8 herds; vaccine 2 [V2], 6 herds); another 6 farms (V3) used a two dose vaccination strategy. Gross lesions of 854 lungs and histopathology from 140 lungs were quantified, and a quantitative PCR was applied to detect M. hyopneumoniae and porcine circovirus 2 (PCV2) DNA in lung tissue (n=140). In addition, porcine reproductive and respiratory disease virus (PRRSV), swine influenza virus (SIV), Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida were tested by qualitative PCR. 53% of lungs were positive for M. hyopneumoniae. 55.9% of lungs showed macroscopic enzootic pneumonia (EP)-like lesions. Lung lesion scores (P<0.001) and M. hyopneumoniae-loads (P<0.008) differed significantly among the vaccination groups, with the most severe cases and highest amounts occurring in V1. Histological alterations differed (P<0.001) between V1 and V3. Lung lesion scores and histopathological changes were significantly correlated, with prevalence and load of M. hyopneumoniae indicating that the applied diagnostic tools are valuable in confirming the prevalence and severity of M. hyopneumoniae infections. Comparing different vaccination strategies against M. hyopneumoniae indicates varying levels of protection. M. hyopneumoniae is still a major problem despite the widely applied vaccination. </AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hillen</LastName><ForeName>Sonja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Justus-Liebig-University Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Berg</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>MSD Animal Health, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Köhler</LastName><ForeName>Kernt</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute for Veterinary Pathology, Justus-Liebig-University Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reinacher</LastName><ForeName>Manfred</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Veterinary Pathology, Justus-Liebig-University Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willems</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Justus-Liebig-University Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiner</LastName><ForeName>Gerald</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Justus-Liebig-University Giessen, Germany. Electronic address: gerald.reiner@vetmed.uni-giessen.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Prev Vet Med</MedlineTA><NlmUniqueID>8217463</NlmUniqueID><ISSNLinking>0167-5877</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001428">Bacterial Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058491" MajorTopicYN="N">Bacterial Load</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001428" MajorTopicYN="N">Bacterial Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045705" MajorTopicYN="N">Mycoplasma hyopneumoniae</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045729" MajorTopicYN="N">Pneumonia of Swine, Mycoplasmal</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Mycoplasma hyopneumoniae</Keyword><Keyword MajorTopicYN="N">Swine</Keyword><Keyword MajorTopicYN="N">Vaccination</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24485705</ArticleId><ArticleId IdType="pii">S0167-5877(13)00394-2</ArticleId><ArticleId IdType="doi">10.1016/j.prevetmed.2013.12.012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Hillen, Sonja" sort="Hillen, Sonja" uniqKey="Hillen S" first="Sonja" last="Hillen">Sonja Hillen</name></noRegion><name sortKey="Kohler, Kernt" sort="Kohler, Kernt" uniqKey="Kohler K" first="Kernt" last="Köhler">Kernt Köhler</name><name sortKey="Reinacher, Manfred" sort="Reinacher, Manfred" uniqKey="Reinacher M" first="Manfred" last="Reinacher">Manfred Reinacher</name><name sortKey="Reiner, Gerald" sort="Reiner, Gerald" uniqKey="Reiner G" first="Gerald" last="Reiner">Gerald Reiner</name><name sortKey="Von Berg, Stephan" sort="Von Berg, Stephan" uniqKey="Von Berg S" first="Stephan" last="Von Berg">Stephan Von Berg</name><name sortKey="Willems, Hermann" sort="Willems, Hermann" uniqKey="Willems H" first="Hermann" last="Willems">Hermann Willems</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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